Loteprednol (as Loteprednol Etabonate) is a topical corticoid antiinflammatory. It is used in ophthalmic solution for the treatment of steroid responsive inflammatory conditions of the eye such as allergic conjunctivitis, uveitis, acne rosacea, superficial punctate keratitis, herpes zoster keratitis, iritis, cyclitis, and selected infective conjunctivitides. As a nasal spray, is used for the. Loteprednol etabonate: efficacy and safety studies. The efficacy and safety of loteprednol etabonate ophthalmic suspension 0.5 % for the treatment of postoperative inflammation has been demonstrated by several studies over the last decade (Table 1). Steroids, such as loteprednol etabonate and fluorometholone are less potent, but have safer side effect profiles. Compared to dexamethasone and prednisolone, loteprednol etabonate and fluorometholone are reported to have lower rates of intraocular pressure (IOP) spikes. Loteprednol etabonate is lipid soluble and can penetrate into cells. Loteprednol etabonate undergoes a predictable transformation to an inactive metabolite. Based upon in vivo and in vitro preclinical metabolism studies, loteprednol etabonate undergoes extensive metabolism to inactive carboxylic acid metabolites, PJ-91 and PJ-90. The loteprednol etabonate is a corticosteroid related to and derived from prednisolone. As As for other corticosteroids, the mode of action is reported to be unknown, but may be due to Further research into the mechanisms of action of steroids—both for their anti-inflammatory effects and for ADRs—is underway. Herein, we review the design of new corticosteroids through retrometabolic design and review available data from preclinical and clinical studies of loteprednol etabonate (LE), the first retrometabolically. Lotemax ® (loteprednol etabonate ophthalmic suspension) contains a sterile, topical anti-inflammatory corticosteroid for ophthalmic use. Loteprednol etabonate is a white to off-white powder. Loteprednol is highly lipid soluble and penetrates cells readily to induce the production of lipocortins. These proteins modulate the activity of prostaglandins and leukotrienes. These proteins modulate the activity of prostaglandins and leukotrienes. LOTEMAX® (loteprednol etabonate) Ophthalmic Suspension 0.5%. STERILE OPHTHALMIC SUSPENSION. DESCRIPTION. LOTEMAX® (loteprednol etabonate ophthalmic suspension) contains a sterile, topical anti-inflammatory corticosteroid for ophthalmic use. Loteprednol (as the ester loteprednol etabonate) is a corticosteroid used to treat inflammations of the eye. It is marketed by Bausch and Lomb as Lotemax and Loterex. Medical uses. Applications for this drug include the reduction of inflammation after eye surgery, seasonal allergic conjunctivitis, uveitis, as well as chronic forms of keratitis (e.g. adenoviral and Thygeson's keratitis), vernal.